The novel anticonvulsant BIA 2-093 inhibits transmitter release during opening of voltage-gated sodium channels: a comparison with carbamazepine and oxcarbazepinePARADA, Antonio; SOARES-DA-SILVA, Patricio.Neurochemistry international. 2002, Vol 40, Num 5, pp 435-440, issn 0197-0186Article

Metabolism of two new antiepileptic drugs and their principal metabolites S( + )- and R(-)-10,11-dihydro-10-hydroxy carbamazepineHAINZL, Dominik; PARADA, Antonio; SOARES-DA-SILVA, Patricio et al.Epilepsy research. 2001, Vol 44, Num 2-3, pp 197-206, issn 0920-1211Article

Pharmacokinetics and drug interactions of eslicarbazepine acetateBIALER, Meir; SOARES-DA-SILVA, Patricio.Epilepsia (Copenhagen). 2012, Vol 53, Num 6, pp 935-946, issn 0013-9580, 12 p.Article

Interferon-γ-induced STAT1-mediated membrane retention of NHE1 and associated proteins ezrin, radixin and moesin in HT-29 cellsMAGRO, Fernando; FRAGA, Sonia; SOARES-DA-SILVA, Patricio et al.Biochemical pharmacology. 2005, Vol 70, Num 9, pp 1312-1319, issn 0006-2952, 8 p.Article

Pharmacokinetic and pharmacodynamic profiles of BIA 3-202, a novel catechol-O-methyltransferase (COMT) inhibitor, during multiple-dose administration to healthy subjectsALMEIDA, Luis; SOARES-DA-SILVA, Patricio.Journal of clinical pharmacology. 2003, Vol 43, Num 12, pp 1350-1360, issn 0091-2700, 11 p.Article

Signaling of short- and long-term regulation of intestinal epithelial type 1 Na⁺/H⁺ exchanger by interferon-γMAGRO, Fernando; FRAGA, Sonia; SOARES-DA-SILVA, Patricio et al.British journal of pharmacology. 2005, Vol 145, Num 1, pp 93-103, issn 0007-1188, 11 p.Article

Dopamine acutely decreases type 3 Na⁺/H⁺ exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascadesGOMES, Pedro; SOARES-DA-SILVA, Patricio.European journal of pharmacology. 2004, Vol 488, Num 1-3, pp 51-59, issn 0014-2999, 9 p.Article

High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK₁ renal cellsSOARES-DA-SILVA, Patricio; SERRAO, Maria Paula.American journal of physiology. Renal physiology. 2004, Vol 56, Num 2, pp F252-F261, issn 1931-857XArticle

Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone)SOARES-DA-SILVA, Patricio; VIEIRA-COELHO, Maria A; PARADA, Antonio et al.Pharmacology & toxicology. 2003, Vol 92, Num 6, pp 272-278, issn 0901-9928, 7 p.Article

The effects of eslicarbazepine on persistent Na⁺ current and the role of the Na⁺ channel β subunitsDOESER, Anna; SOARES-DA-SILVA, Patricio; BECK, Heinz et al.Epilepsy research. 2014, Vol 108, Num 2, pp 202-211, issn 0920-1211, 10 p.Article

Intestinal Na⁺-K⁺-ATPase activity and molecular events downstream of interferon-γ receptor stimulationMAGRO, Fernando; FRAGA, Sonia; RIBEIRO, Tomé et al.British journal of pharmacology. 2004, Vol 142, Num 8, pp 1281-1292, issn 0007-1188, 12 p.Article

The L-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchangerFRAGA, Sonia; SERRAO, Maria Paula; SOARES-DA-SILVA, Patricio et al.European journal of pharmacology. 2002, Vol 441, Num 3, pp 127-135, issn 0014-2999Article

High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive ratsPINHO, Maria Joao; SERRAO, Maria Paula; SOARES-DA-SILVA, Patricio et al.American journal of physiology. Renal physiology. 2007, Vol 61, Num 5, issn 1931-857X, F1452-F1463Article

Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D₁ receptor in rat IEC-6 intestinal epithelial cellsFRAGA, Sonia; JOSE, Pedro A; SOARES-DA-SILVA, Patricio et al.American journal of physiology. Regulatory, integrative and comparative physiology. 2004, Vol 56, Num 4, pp R772-R779, issn 0363-6119Article

Effect of eslicarbazepine acetate in the corneal kindling progression and the amygdala kindling model of temporal lobe epilepsyPOTSCHKA, Heidrun; SOERENSEN, Jonna; PEKCEC, Anton et al.Epilepsy research. 2014, Vol 108, Num 2, pp 212-222, issn 0920-1211, 11 p.Article

Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferaseLEARMONTH, David A; NUNO PALMA, P; VIEIRA-COELHO, Maria A et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 25, pp 6207-6217, issn 0022-2623, 11 p.Article

Transport of the organic cations gonyautoxin 2/3 epimers, a paralytic shellfish poison toxin, through the human and rat intestinal epitheliumsANDRINOLO, Dario; GOMES, Pedro; FRAGA, Sonia et al.Toxicon (Oxford). 2002, Vol 40, Num 10, pp 1389-1397, issn 0041-0101, 9 p.Article

G_iα3 protein-coupled dopamine D₃ receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated eventPEDROSA, Rui; GOMES, Pedro; HOPFER, Ulrich et al.American journal of physiology. Renal physiology. 2004, Vol 56, Num 5, pp F1059-F1066, issn 1931-857XArticle

Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitorBONIFACIO, Maria Joao; VIEIRA-COELHO, Maria Augusta; SOARES-DA-SILVA, Patricio et al.European journal of pharmacology. 2003, Vol 460, Num 2-3, pp 163-170, issn 0014-2999, 8 p.Article

Why healthy subjects volunteer for phase I studies and how they perceive their participation?ALMEIDA, Luis; AZEVEDO, Benedita; NUNES, Teresa et al.European journal of clinical pharmacology. 2007, Vol 63, Num 11, pp 1085-1094, issn 0031-6970, 10 p.Article

Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024AMBROSIO, Antonio F; SOARES-DA-SILVA, Patricio; CARVALHO, Caetana M et al.Neurochemical research. 2002, Vol 27, Num 1-2, pp 121-130, issn 0364-3190Article

D₁-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitorsVIEIRA-COELHO, Maria Augusta; GOMES, Pedro; SERRAO, Maria Paula et al.Kidney international. 2000, Vol 59, Num 5, pp 1683-1694, issn 0085-2538Article

Optimization of a Parallel Artificial Membrane Permeability Assay for the Fast and Simultaneous Prediction of Human Intestinal Absorption and Plasma Protein Binding of Drug Candidates: Application to Dibenz[b,f]Azepine-5-Carboxamide DerivativesFORTUNE, Ana; ALVES, Gilberto; SOARES-DA-SILVA, Patrício et al.Journal of pharmaceutical sciences. 2012, Vol 101, Num 2, pp 530-540, issn 0022-3549, 11 p.Article

Effect of Eslicarbazepine Acetate on the Steady-State Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Subjects During a Three-Stage, Open-Label, Multiple-Dose, Single-Period StudyVAZ-DA-SILVA, Manuel; ALMEIDA, Luis; FALCAO, Amilcar et al.Clinical therapeutics. 2010, Vol 32, Num 1, pp 179-192, issn 0149-2918, 14 p.Article

Who volunteers for phase I clinical trials? Influences of anxiety, social anxiety and depressive symptoms on self-selection and the reporting of adverse eventsALMEIDA, Luis; KASHDAN, Todd B; NUNES, Teresa et al.European journal of clinical pharmacology. 2008, Vol 64, Num 6, pp 575-582, issn 0031-6970, 8 p.Article